Rederivation of Mouse Lines
Rederivation of mouse lines in an SPF (Specific Pathogen-Free) environment is an important procedure for eradicating pathogens within an animal facility. Pathogens, even if they do not cause clinical diseases, can alter the physiological state of the animal and interfere with experimental analysis. Mouse lines with pathogens can be rederived into a pathogen-free state by transferring embryos from a contaminated mouse to a recipient mother in a pathogen-free area. The resulting mice from this procedure will be pathogen-free. Rederivations of mice can be performed in both heterozygous and homozygous states.